Cell BiologybioRxiv
Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice
Hyung-Seok Kim, Mary L Sanchez, Joshua Silva…·Jan L. Christian
This study shows that mutations preventing phosphorylation of BMP4's prodomain impair its proteolytic activation in homodimers, causing lethality in mice.
5 citations