Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells
Patrick J. Brennan, Rebecca E. Saunders, Mary Spanou, Sarah E. Singleton, M. Teresa Serafini, Liang Sun, Guillaume Heger, Agnieszka Konopacka, Ryan D. D. Beveridge, C. Cameron Taylor, Peter DePaola, Laurie Gordon, Shenaz B. Bunally, Aurore Saudemont, Andrew B. Benowitz, , Stuart J. Conway
The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.
ACS Chemical Biology · Nov 2, 2025Peer-reviewedBiochemistry