Author

Carlos Martinez-Fleites

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Markus A. QueisseriD· 2 shared Agnieszka KonopackaiD· 1 shared Andrew B. BenowitziD· 1 shared Aurore SaudemontiD· 1 shared C. Cameron Taylor· 1 shared Charlotte Mary DeaneiD· 1 shared Daniel ConoleiD· 1 shared Danielle L. SchmittiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Markus A. QueisserORCID

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Author profile →

2 papers

Recent·Most cited

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

Patrick J. Brennan, Rebecca E. Saunders, Mary Spanou, Sarah E. Singleton, M. Teresa Serafini, Liang Sun, Guillaume Heger, Agnieszka Konopacka, Ryan D. D. Beveridge, C. Cameron Taylor, Peter DePaola, Laurie Gordon, Shenaz B. Bunally, Aurore Saudemont, Andrew B. Benowitz, , Stuart J. Conway

The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.

ACS Chemical Biology · Nov 2, 2025Peer-reviewedBiochemistry

Structure-guided design and optimization of covalent VHL-targeted sulfonyl fluoride PROTACs

Rishi R. Shah, Elena De Vita, Preethi Soundarya Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R. Dickinson, Carlos Martinez-Fleites, Markus A. Queisser, John D. Harling, Edward W. Tate

This study designs and optimizes covalent VHL-targeted sulfonyl fluoride PROTACs that degrade BRD4 and androgen receptor without linker optimization.

Journal of Medicinal Chemistry · Mar 13, 2024Peer-reviewedMolecular Biology