Danielle L. Schmitt

The paper develops a fluorescent biosensor to measure methionine dynamics with high spatiotemporal resolution and applies it to study methionine metabolism in cells and in vivo.

This paper develops a phase separation-based PINK1 biosensor to visualize real-time PINK1 activity in single live cells and study its role in mitophagy.

The paper develops a genetically encoded biosensor, iGlo, to study glutamine metabolism dynamics across organelles and cells, revealing temporal crosstalk between glucose and glutamine metabolism.

This study shows that LKB1 spatially regulates AMPK activity in response to oxidative stress, affecting metabolic and gene expression changes, and identifies impaired LKB1-AMPK signaling in certain cancers.

The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.

This paper develops a genetically encoded fluorescent biosensor, Malibu, to measure intracellular malonyl-CoA dynamics in single cells, showing increased responses to fatty acid biosynthesis inhibitors.

The paper develops a sensitive AMPK activity reporter, ExRai AMPKAR, to study subcellular AMPK dynamics and reveals differential regulation of AMPK activity at lysosomes, mitochondria, and the nucleus.