FTO separation-of-function mutations alter m6A versus m6Am demethylation selectivity on RNA
Kasun Dilshan Abeyrathne Eluwawalage, Brittany A. Shimanski, Marcin Warmiński, Suma Katta, Rebecca Payne, Yanbao Yu, Joanna Kowalska, Jacek Jemielity, Jeffrey S. Mugridge
This paper reports engineered FTO mutants that selectively demethylate m6A or m6Am RNA modifications, enabling study of their distinct biological roles.
bioRxiv · May 19, 2026 · PreprintBiochemistry