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Reese C Guitche

University of California, San Francisco

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Genetics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

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Alexander MarsoniD· 1 shared Ansuman T. SatpathyiD· 1 shared Austin HartmaniD· 1 shared Emma DanniD· 1 shared Jonathan K. PritchardiD· 1 shared Jun YaniD· 1 shared Justine Reyes Retana· 1 shared Lillian Brixi· 1 shared

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Alexander MarsonORCID

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1 paper

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GeneticsCellPeer-reviewedAug 28, 2026

✦ In-depth digest

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

Ronghui Zhu, Emma Dann, Jun Yan…·Alexander Marson

Genome-scale CRISPRi perturb-seq in 22 million primary human CD4+ T cells maps stimulation-specific regulators and links perturbation signatures to T cell states and autoimmune genetics.

24 citationstop 1%

humanscRNA-seq

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