Nanoscopy Reveals Heparan Sulfate Clusters as Docking Sites for SARS-CoV-2 Attachment and Entry
Sue Han, Xin Wang, Tiansheng Li, Ammar Mohseni, Ivan Košík, Chung Yu Chan, Alberto Domingo López-Muñoz, Jessica Matthias, Reid Suddaby, Zhixiong Wang, Albert J. Jin, Christian A. Wurm, Jonathan Wilson Yewdell, Ling‐Gang Wu
This paper uses advanced microscopy to show that SARS-CoV-2 attaches to and enters cells via heparan sulfate clusters, not ACE2, and that blocking HS binding inhibits viral infection.
bioRxiv · Sep 8, 2025Microbiology