Jessica Matthias

This paper identifies an allosteric checkpoint in CD16a that regulates NK cell ADCC independently of IgG-Fc binding, revealing a mechanism for modulating immune responses.

The paper shows that LD-targeted proteins are confined by nanodomains and transported via ER-LD bridges, revealing mechanisms for their selective accumulation on lipid droplets.

The paper tracks chromatin dynamics across seven orders of magnitude in human and mouse cells, finding strongly subdiffusive behavior with limited sensitivity to transcription and histone modifications.

This paper introduces caging-group-free photoactivatable fluorophores with far-red emission for improved super-resolution microscopy.

This paper uses advanced microscopy to show that SARS-CoV-2 attaches to and enters cells via heparan sulfate clusters, not ACE2, and that blocking HS binding inhibits viral infection.

This study uses MINFLUX nanoscopy to map CD16a spatial distribution in NK cells, revealing CD16a pairs and increased density at synapses during ADCC activation.

The paper shows that active zone maturation state determines synaptic release mode and strength, and that neuronal activity regulates AZ number and size during development.

This study identifies a two-heads-bound state in KIF1A that enhances processivity and is critical for neuronal transport, contrasting with Kinesin-1's one-head-bound state.