Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule
Hiroki Akiba, Tomoko Ise, Reiko Satoh, Yasuhiro Abe, Kouhei Tsumoto, Hiroaki Ohno, Haruhiko Kamada, Satoshi Nagata
This study develops biparatopic anti-CD30 antibodies by determining epitopes and analyzing their agonistic and antagonistic activities.
Antibody Therapeutics · Jan 1, 2025Peer-reviewedBiochemistry