Kouhei Tsumoto

The paper determines the Cryo-EM structure of the intestinal IMAC complex, revealing its heterotetrameric composition and structural features that enable microvilli adhesion and resilience to shear stress.

This study shows that thioester domains in bacterial adhesins enable pH-responsive covalent adhesion, with reversible binding regulated by pH changes.

The paper investigates the interaction of rifampicin and related compounds with CYP143 in M. tuberculosis, revealing binding modes and structural insights into resistance mechanisms.

This paper introduces a method to create synthetic chemo-optogenetic tools by combining rational small-molecule design with TRAP display to generate light-controlled protein binders.

This study develops biparatopic anti-CD30 antibodies by determining epitopes and analyzing their agonistic and antagonistic activities.

This study identifies PfHO as essential for apicoplast biogenesis and gene expression in Plasmodium falciparum, revealing its role in maintaining apicoplast-encoded RNA levels.