Hiroaki Ohno

Membrane progesterone receptors PAQR6 and PAQR8 in the ruminant uterus and ovary

This study maps the expression of PAQR6 and PAQR8 in ruminant reproductive tissues using antibodies and qPCR, showing their localization and dynamic gene expression changes during pregnancy.

Size-dependent effect of site-specific polyethylene glycol modification of trastuzumab on the antibody functions

This study evaluates how site-specific PEG modification and PEG size affect trastuzumab's antibody functions, finding size-dependent reductions in ADCC activity and antigen/Fc receptor interactions.

Cell-type-specific expression of classical and membrane progesterone receptors at the human maternal-fetal interface

The paper identifies cell-type-specific expression patterns of classical and membrane progesterone receptors at the human maternal-fetal interface using single-cell and spatial transcriptomic data.

Maternal progesterone signaling establishes lifelong oral homeostasis

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.

Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region

The paper converts an agonistic anti-TNFR2 biparatopic antibody into an antagonist by inserting peptide linkers into the hinge region, altering its immunocomplex formation.

Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state

This study shows that maternal progesterone and adipose mPRε regulate the embryonic nutritional state by affecting glucose provision and metabolic outcomes in offspring.

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule

This study develops biparatopic anti-CD30 antibodies by determining epitopes and analyzing their agonistic and antagonistic activities.