The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.
Jennifer Stables, Reiss Pal, Barry Matthew Bradford, Dylan Carter‐Cusack, Isis Taylor, Clare Pridans, Nemat Khan, Trent M. Woodruff, Katharine M. Irvine, KIM M. SUMMERS, Neil Andrew Mabbott, David Arthur Hume
This study examines the impact of a heterozygous Csf1r mutation on brain development and neuropathology in mice, showing reduced microglial abundance and altered gene expression in disease models.
Neurobiology of Disease · Nov 22, 2024Peer-reviewedNeuroscience