KIM M. SUMMERS

This study shows that mice with a germ-line deletion of a Csf1r enhancer lack specific macrophages but maintain normal physiology and can be replenished by donor cells.

The paper identifies transcriptomic signatures in aphthous ulcers of Crohn's disease, suggesting bacterial invasion initiates inflammation rather than dysbiosis.

This study shows that wild-type bone marrow cells can restore macrophage populations and reverse developmental defects in Csf1rko rats, but not in the brain.

The paper shows that wild-type bone marrow-derived microglia-like cells reduce strain-dependent neuropathology in Csf1r mutant mice by preventing thalamic calcification.

This study examines the impact of a heterozygous Csf1r mutation on brain development and neuropathology in mice, showing reduced microglial abundance and altered gene expression in disease models.

This study defines a therapeutic window for prion disease by showing early Prnp depletion halts progression, but later depletion does not, using a mouse model with time-dependent Prnp manipulation.

This study examines transcriptomic variation in macrophages from IBD families and finds extreme individual variation in gene expression linked to HLA genotype and genetic susceptibility to IBD.

The paper generates a rat RNA-seq transcriptomic atlas and uses gene correlation networks to identify tissue-specific transcript clusters and biological processes.

This study investigates a kinase-dead Csf1r mutation in mice, showing it causes dominant-negative effects on CSF1R signaling and impacts macrophage development and brain microglia.

This study shows that Csf1r mutation in mice, rats, and humans causes developmental defects, and bone marrow transfer can reverse some phenotypes by restoring macrophages.

This paper reports unexpected severe hydrops fetalis in CRISPR-Cas9 edited pigs with a FBN1 deletion, highlighting potential off-target effects and the need for comprehensive genomic analysis.

This study investigates gene expression in sheep cardiovascular tissues to understand vascular calcification, highlighting gene balance and extracellular matrix roles.

The paper reports a CRISPR-Cas9-induced deletion and reinsertion event in the mouse Csf1r promoter, highlighting the need for copy number analysis to confirm genomic edits.

This study identifies X chromosome variants associated with neuroticism using UK Biobank data, finding 204 significant markers and estimating X-variant heritability at 0.34%.

The paper identifies a missense variant in OLFML3 as a candidate for severe goniodysgenesis and glaucoma in Border Collies.

The paper develops a graph-based visualization method for RNA-Seq data to better understand transcript diversity and assembly issues.

The paper integrates public and new RNA-seq data to create a chicken mRNA expression atlas, revealing tissue-specific gene clusters and developmental patterns.

This study shows that environmental enrichment in pigs increases neuronal activity and synaptic plasticity genes while reducing microglial activity, similar to findings in rodents.

This study identifies TIM4-expressing mononuclear phagocytes in chickens, distinguishing phagocytic Kupffer cells from non-phagocytic DC-like cells using CSF1R reporters.

This paper presents a high-resolution gene expression atlas for sheep, identifying transcriptional signatures and functional annotations across tissues and developmental stages.