Barry Matthew Bradford

Wild type bone marrow-derived microglia-like cells mitigate strain-dependent neuropathology in Csf1r mutant mice.

The paper shows that wild-type bone marrow-derived microglia-like cells reduce strain-dependent neuropathology in Csf1r mutant mice by preventing thalamic calcification.

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.

This study examines the impact of a heterozygous Csf1r mutation on brain development and neuropathology in mice, showing reduced microglial abundance and altered gene expression in disease models.

Therapeutic window for treatment of prion disease defined by timed depletion of Prion protein

This study defines a therapeutic window for prion disease by showing early Prnp depletion halts progression, but later depletion does not, using a mouse model with time-dependent Prnp manipulation.

Complete microglia deficiency accelerates prion disease without enhancing CNS prion accumulation

This study shows that complete microglia deficiency accelerates CNS prion disease without increasing prion accumulation, suggesting microglia protect against astrocyte-driven pathology rather than clearing prions.