Abnormal microtubule dynamics disrupt nucleocytoplasmic transport in tau-mediated frontotemporal dementia
Francesco Paonessa, Lewis Evans, Rekha Solanki, Delphine Larrieu, Selina Wray, John Hardy, Stephen P. Jackson, Frederick J. Livesey
This study shows that tau mutations in FTD cause hyperphosphorylation, mislocalization, and nuclear membrane deformation, leading to defective nucleocytoplasmic transport.
bioRxiv · May 22, 2018 · PreprintNeuroscience