Delphine Larrieu

A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein translation

A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.

Patching up the nucleus: a novel role for PMLII in nuclear envelope rupture repair

This study identifies PMLII as forming biomolecular condensates at sites of nuclear envelope disruption, suggesting a role in stabilizing the site for repair.

Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo Drosophila tauopathy model

The paper shows that inhibiting NAT10 corrects nuclear defects and extends lifespan in tauopathy models.

Abnormal microtubule dynamics disrupt nucleocytoplasmic transport in tau-mediated frontotemporal dementia

This study shows that tau mutations in FTD cause hyperphosphorylation, mislocalization, and nuclear membrane deformation, leading to defective nucleocytoplasmic transport.