Epigenetic suppression of SLFN11 in germinal center B cells in the process of the dynamic expression change during B-cell development
Fumiya Moribe, Momoko Nishikori, Tsuyoshi Takashima, Daiki Taniyama, Nobuyuki Onishi, Hiroshi Arima, Hiroyuki Sasanuma, Remi Akagawa, Fathi Elloumi, Shunichi Takeda, Yves G. Pommier, Eiichi Morii, Akifumi Takaori‐Kondo, Junko Murai
The paper examines SLFN11 expression in B-cell development and lymphomas, finding it is epigenetically suppressed in germinal center B cells and that epigenetic modifiers enhance its expression, increasing sensitivity to cytosine arabinoside.
PLoS ONE · Jan 29, 2021Peer-reviewedMolecular Biology