Hiroyuki Sasanuma

This paper shows BRCA2 loss causes genomic instability through ROS-dependent metabolic collapse, highlighting the role of glutathione metabolism and PARP inhibitors in cell death.

This study identifies REV7 as a novel binding partner of ATRIP that inhibits ATR kinase activity and negatively regulates ATR signaling.

The paper shows neuronal migration in developing brains causes DNA damage through mechanostress, which is repaired normally but can lead to disease if unresolved.

This study investigates how acetaldehyde-induced DNA damage is repaired, finding that homologous recombination and TDP1/TDP2 play critical roles in repair efficiency.

The paper examines SLFN11 expression in B-cell development and lymphomas, finding it is epigenetically suppressed in germinal center B cells and that epigenetic modifiers enhance its expression, increasing sensitivity to cytosine arabinoside.

This study investigates how human nucleotide excision repair and DNA polymerase η process single ribonucleotides in DNA, showing their roles in mutagenesis and repair outcomes.