Modular control of CpG islands by chromatin-opening transcription factors specifies transcription start sites
Fumiya Moribe, Murat Iskar, Sevi Durdu, Christiane Wirbelauer, Leslie Hoerner, Sebastien Smallwood, Lukas Burger, Dirk Schübeler
The paper shows chromatin-opening transcription factors determine transcription start sites by binding near the initiation site, with loss of these factors redirecting initiation to secondary sites.
bioRxiv · May 6, 2026 · PreprintMolecular Biology