Shunichi Takeda

This study identifies FA-induced DNA-protein crosslinks (DPCs) and discovers that FEN1 repairs them via PARylation, revealing a novel PARP1-FEN1 pathway for DPC repair.

The paper analyzes whole-genome sequencing data from DNA repair-deficient cell lines to identify mutational signatures linked to aging and temozolomide chemotherapy.

This study shows that TDP2 regulates estrogen-induced oncogene expression by resolving TOP2-induced DNA breaks, affecting MYC and CCND1 in ER-positive cells and mice.

The paper examines SLFN11 expression in B-cell development and lymphomas, finding it is epigenetically suppressed in germinal center B cells and that epigenetic modifiers enhance its expression, increasing sensitivity to cytosine arabinoside.

This study investigates how human nucleotide excision repair and DNA polymerase η process single ribonucleotides in DNA, showing their roles in mutagenesis and repair outcomes.