SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 Nef
Cinzia Bertelli, Annachiara Rosa, Teresa Vanzo, Irene Crescioli, Hamza Ur Rehman, Ajit G. Chande, Remigiusz Serwa, Edward W. Tate, Peter Cherepanov, Massimo Pizzato
This paper identifies SERINC5 as the primary target of retroviral antagonists and shows that a tri-cysteine motif in intracellular loop 4 is critical for its downregulation by HIV-1 Nef.
Journal of Virology · Oct 12, 2026Peer-reviewedMicrobiology