SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 Nef
Cinzia Bertelli, Annachiara Rosa, Teresa Vanzo…·Massimo Pizzato
This paper identifies SERINC5 as the primary target of retroviral antagonists and shows that a tri-cysteine motif in intracellular loop 4 is critical for its downregulation by HIV-1 Nef.