Alterations in DNA 5-hydroxymethylation Patterns in the Hippocampus of an Experimental Model of Refractory Epilepsy
Rudhab Bahabry, Rebecca M. Hauser, Richard G. Sánchez, Silvienne Sint Jago, Lara Ianov, Remy J. Stuckey, R. Ryley Parrish, Lawrence Ver Hoef, Farah D. Lubin
The paper investigates DNA 5-hydroxymethylation (5-hmC) changes in TLE patients and a rat model, finding reduced 5-hmC levels and specific gene associations, with Tet1 manipulation affecting seizure outcomes.
bioRxiv · Oct 3, 2023 · PreprintNeuroscience