The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatin
Yuxiang Zhang, Qian Sun, Zhiyong Ji, Ren Mo, Yuchuan Zhou, Jingpeng Zhao, Shuai Xu, Na Li, Yifan Sun, Haowei Bai, Erlei Zhi, Sha Han, Huixing Chen, Jing Zhang, Dewei Qian, , Chencheng Yao
The paper identifies a missense variant in the XPF-like domain of SHOC1 that disrupts meiotic recombination and causes meiotic arrest by impairing DNA repair and chromatin structure.
bioRxiv · May 28, 2025 · PreprintDevelopmental Biology