Chencheng Yao

This paper develops a spermatocytes-tropic mRNA-LNP delivery system to treat genetic spermatogenic disorders, showing restoration of spermatogenesis in mouse models.

This study identifies senescent mast cells as drivers of benign prostatic hyperplasia through SCF/c-KIT-mediated endothelial-mesenchymal transition.

The paper identifies a missense variant in the XPF-like domain of SHOC1 that disrupts meiotic recombination and causes meiotic arrest by impairing DNA repair and chromatin structure.

The paper introduces MHA, a single-cell RNA sequencing database for male genitourinary development and disease, offering user-friendly tools for gene expression analysis and visualization.

This study creates a single-cell atlas of human testicular development and NOA patients, revealing Sertoli cell maturation defects and potential therapeutic strategies.

This study reprograms human fibroblasts into Sertoli cells using NR5A1 and GATA4, showing they resemble primary Sertoli cells and support spermatogonia viability and immune suppression.