Author

Sha Han

Shanghai Jiao Tong UniversityORCID 0000-0002-4044-0700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Chencheng YaoiD· 2 shared Dewei QianiD· 2 shared Erlei ZhiiD· 2 shared Fujun ZhaoiD· 2 shared Haowei Bai· 2 shared Jingpeng ZhaoiD· 2 shared Ruhui TianiD· 2 shared Shuai XuiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Chencheng YaoORCID

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2 papers

Recent·Most cited

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, , Chencheng Yao

This paper develops a spermatocytes-tropic mRNA-LNP delivery system to treat genetic spermatogenic disorders, showing restoration of spermatogenesis in mouse models.

Advanced Science · Feb 11, 2026Peer-reviewedMolecular Biology

The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatin

Yuxiang Zhang, Qian Sun, Zhiyong Ji, Ren Mo, Yuchuan Zhou, Jingpeng Zhao, Shuai Xu, Na Li, Yifan Sun, Haowei Bai, Erlei Zhi, Sha Han, Huixing Chen, Jing Zhang, Dewei Qian, , Chencheng Yao

The paper identifies a missense variant in the XPF-like domain of SHOC1 that disrupts meiotic recombination and causes meiotic arrest by impairing DNA repair and chromatin structure.

bioRxiv · May 28, 2025 · PreprintDevelopmental Biology