Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking
Ryan M. Loughran, Gurpreet K. Arora, Jiachen Sun, Alicia Llorente Lope, Sophia Crabtree, Cynthia Y. Zhang, Kyanh Ly, Ren-Li Huynh, Wonhwa Cho, Brooke E. Emerling
This study identifies PI(4,5)P2's role in lysosome positioning through cholesterol trafficking in p53-deficient cancers.
Science Advances · May 22, 2026Peer-reviewedCell Biology