Author

Brooke M. Emerling

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0002-2168-4582Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Alicia Llorente LopeiD· 2 shared Cynthia Y. Zhang· 2 shared Gurpreet K. AroraiD· 2 shared Kyanh LyiD· 2 shared Ryan M. LoughraniD· 2 shared Sophia CrabtreeiD· 2 shared Andrej BenjakiD· 1 shared Benji Portillo· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Alicia Llorente LopeORCID

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3 papers

Recent·Most cited

Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking

Ryan M. Loughran, Gurpreet K. Arora, Jiachen Sun, Alicia Llorente Lope, Sophia Crabtree, Cynthia Y. Zhang, Kyanh Ly, Ren-Li Huynh, Wonhwa Cho, Brooke E. Emerling

This study identifies PI(4,5)P2's role in lysosome positioning through cholesterol trafficking in p53-deficient cancers.

Science Advances · May 22, 2026Peer-reviewedCell Biology

PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer

Gurpreet K. Arora, Ryan M. Loughran, Kyanh Ly, Cheska Marie Galapate, Alicia Llorente Lope, Taylor R. Anderson, Cynthia Y. Zhang, Shea F. Grenier, Ling Li, Sophia Crabtree, Guillem Lambies, Chantal Pauli, David A. Scott, Yoav Altman, Benji Portillo, , Brooke M. Emerling

This study identifies PI5P4K as a regulator of iron homeostasis in pancreatic cancer cells, showing its role in metabolic fitness and tumor growth.

Cell Reports · Aug 29, 2025Peer-reviewedCancer Biology

Loss of PI5P4Kalpha slows the progression of a Pten mutant basal cell model of prostate cancer

Joanna Triscott, Marika Lehner, Andrej Benjak, Matthias Reist, Brooke M. Emerling, Charlotte K.Y. Ng, Simone de Brot, Mark A. Rubin

The paper shows that loss of PI5P4K slows cancer progression in prostate basal cells by disrupting lipid metabolism in a Pten mutant model.

Molecular Cancer Research · Oct 9, 2024Peer-reviewedCancer Biology