Phase separation reshapes the conformational energy landscape of a chaperone to prime its activity
Rashik Ahmed, Lucia Svoboda, Rhea P Hudson, Jeffrey P. Bonin, Bernd Bukau, Julie Deborah Forman-Kay, Lewis E. Kay
This study shows how phase separation alters the conformational dynamics of DNAJB1, priming it for HSP70 binding and stress granule disassembly.
bioRxiv · Oct 22, 2026 · PreprintBiophysics