De novo design of semisynthetic protein nanopores
Lee Schnaider, A. Katherine Hatstat, Alistair J. Scott, Sophia K. Tan, Richard G. Hambley, William Dawson, Rhys C. Griffiths, Rian C. Kormos, Arthur Alves de Melo, Eric Tse, Nicholas F. Polizzi, Elizabeth Jayne Wallace, Gregory E. Merz, William F. DeGrado
This paper designs de novo proteins to modify nanopore complexes, creating customized structural and functional properties for enhanced sequencing applications.
bioRxiv · Sep 8, 2025 · PreprintBiochemistry