William Dawson

This paper designs de novo proteins to modify nanopore complexes, creating customized structural and functional properties for enhanced sequencing applications.

The paper develops a fluorescence-based assay to study peptide exchange in de novo coiled-coil assemblies and identifies strategies to improve orthogonality between oligomeric states.

The paper engineers an allosteric switch in kinesin-1 motors using de novo peptides, showing increased transport in cells through conformational changes.

The paper updates a database of coiled-coil structures from experimental data and AlphaFold2 models, enabling searches and analysis of coiled-coil assemblies and their sequence-structure relationships.

This paper describes a computational method for designing -helical-barrel proteins with small molecule-binding channels, achieving high expression and structural accuracy in E. coli.