Islet macrophages drive islet remodeling and compensatory hyperinsulinemia in the early diabetes
Manesh Chittezhath, Divya Gunaseelan, Xiaofeng Zheng, Riasat Hasan, Vanessa S. Y. Tay, Seok Ting Lim, Xiaomeng Wang, Per‐Olof Berggren, Stefan Richard Bornstein, Bernhard Otto Boehm, Christiane Ruedl, Yusuf Ali
The paper shows that islet resident macrophages drive islet remodeling and hyperinsulinemia in early type-2 diabetes by promoting vascularization and insulin secretion.
American Journal of Physiology-Endocrinology and Metabolism · Oct 1, 2019Peer-reviewedMolecular Biology