Substrate binding and activation mechanism of the essential bacterial septal cell wall synthase FtsW
Martin Yepes, Nicolás N. Yehya, Amilcar J. Perez, Ribo Xiong, Brooke M. Britton, Albert Y. Lau, Jie Xiao
This study defines the substrate binding and activation mechanism of FtsW using simulations, mutagenesis, and assays, revealing conserved residues and structural constraints involved in lipid II binding and catalysis.
bioRxiv · Feb 14, 2026 · PreprintBiophysics