Author

Nicolás N. Yehya

Johns Hopkins UniversityORCID 0000-0002-8705-900XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Jie XiaoiD· 3 shared Boaz GoldbergiD· 2 shared Sam MeyeriD· 2 shared Albert Y. LauiD· 1 shared Amilcar J. PereziD· 1 shared Brooke M. BrittoniD· 1 shared Christopher H. BohreriD· 1 shared David J. HathcockiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

Jie XiaoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Substrate binding and activation mechanism of the essential bacterial septal cell wall synthase FtsW

Martin Yepes, Nicolás N. Yehya, Amilcar J. Perez, Ribo Xiong, Brooke M. Britton, Albert Y. Lau, Jie Xiao

This study defines the substrate binding and activation mechanism of FtsW using simulations, mutagenesis, and assays, revealing conserved residues and structural constraints involved in lipid II binding and catalysis.

bioRxiv · Feb 14, 2026 · PreprintBiophysics

Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli

Nicolás N. Yehya, Christopher H. Bohrer, Qiwei Yu, David J. Hathcock, Boaz Goldberg, Siqi Leng, Frances E. Harris, Hunter Hendrix, Maxwell White, Fenfei Leng, Sam Meyer, Yuhai Tu, Jie Xiao

This study shows that chromosomal topological domains in E. coli repress transcription, reduce orientation effects, and modulate gene coupling through supercoiling changes.

bioRxiv · Nov 23, 2025 · PreprintBiophysics

Differential effect of supercoiling on bacterial transcription in topological domains

Boaz Goldberg, Nicolás N. Yehya, Jie Xiao, Sam Meyer

This paper develops a computational model to quantify how DNA supercoiling and topoisomerases regulate bacterial transcription, showing distinct roles for topoisomerase I and gyrase in gene expression.

PLoS Computational Biology · Nov 11, 2025Peer-reviewedBiophysics