Author

Brooke M. Britton

Johns Hopkins UniversityORCID 0000-0003-1606-0991Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Jie XiaoiD· 2 shared Albert Y. LauiD· 1 shared Amilcar J. PereziD· 1 shared Atsushi YahashiriiD· 1 shared David S. WeissiD· 1 shared Joshua W. McCauslandiD· 1 shared Martin YepesiD· 1 shared Nicolás N. YehyaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Jie XiaoORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintFeb 14, 2026

Substrate binding and activation mechanism of the essential bacterial septal cell wall synthase FtsW

Martin Yepes, Nicolás N. Yehya, Amilcar J. Perez…·Jie Xiao

This study defines the substrate binding and activation mechanism of FtsW using simulations, mutagenesis, and assays, revealing conserved residues and structural constraints involved in lipid II binding and catalysis.

DOI 10.64898/2026.02.13.705525

E. colistructural biology

𝕏 PostBluesky

MicrobiologyNature MicrobiologyPeer-reviewedMay 27, 2025

E. coli FtsN coordinates synthesis and degradation of septal peptidoglycan by partitioning between a synthesis track and a denuded glycan track

Zhixin Lyu, Xinxing Yang, Atsushi Yahashiri…·Jie Xiao

10 citations

E. coliexperimental assay

𝕏 PostBluesky