Dissecting Annexin-A11 into its functional domains revealed calcium as a key regulator for RNA transport and its association with ALS
Giulia Di Napoli, Lorenzo Alfurno, Alex Fissore, Eleonora Raccuia, Valeria Bincoletto, Paolo Olivieri, Riccardo Scoccia, Fabrizio Dal Piaz, Mauro Marengo, Simonetta Oliaro‐Bosso, Silvia Arpicco, Maela Manzoli, Gianluca Catucci, Gianfranco Gilardi, Adrián Velázquez‐Campoy, , Salvatore Adinolfi
This study identifies calcium as a key regulator of Annexin-A11's function in RNA transport and its disruption in ALS by revealing its conformational switch and domain interactions.
bioRxiv · Oct 27, 2025 · PreprintBiochemistry