Francesco Di Palma

RNA interactions drive structural and functional diversification of alpha-synuclein fibrils

This study shows RNA binding alters the structure, function, and stability of alpha-synuclein fibrils, suggesting RNA as an active co-factor in amyloid formation.

Dissecting Annexin-A11 into its functional domains revealed calcium as a key regulator for RNA transport and its association with ALS

This study identifies calcium as a key regulator of Annexin-A11's function in RNA transport and its disruption in ALS by revealing its conformational switch and domain interactions.

Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS

This study uses RNA aptamers to detect pathological FUS in ALS, showing improved specificity and sensitivity compared to antibodies.

Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment

This paper designs aptamers targeting RAD51-BRCA2 interaction to inhibit RAD51 nuclear recruitment, enhancing DNA damage and cytotoxicity in pancreatic cancer cells.

Probing interplays between human XBP1u translational arrest peptide and 80S ribosome

This study uses molecular dynamics simulations to investigate XBP1u AP-ribosome interactions and their variants, revealing insights into the mechanism of translational arrest.