The proportion of periportal mesenchyme to ductal epithelial cells acts as a proliferative rheostat in liver regeneration
Lucía Cordero-Espinoza, Timo N. Kohler, Anna M. Dowbaj, Bernhard Strauss, Olga Sarlidou, Clare Pacini, Ross Dobie, John R. Wilson‐Kanamori, Richard Butler, Palle Serup, Neil Cowan Henderson, Florian Hollfelder, Meritxell Huch
This study shows that the ratio of periportal mesenchyme to ductal epithelial cells regulates ductal cell proliferation during liver regeneration through Notch signaling.
bioRxiv · Sep 21, 2020 · PreprintDevelopmental Biology