The paper uses in utero barcoding and single-cell transcriptomics to map clonal relationships in mouse mesoderm-derived tissues, revealing lineage relationships in liver and heart mesenchyme.

bioRxiv · Sep 23, 2026 · PreprintDevelopmental Biology

HLiCA: An integrated cell atlas of the healthy human liver

Rachel D. Edgar, Jordan R. Portman, Hongru Hu, Delaram Pouyabahar, Raza R. Rahman, Daniel Stueckmann, Yongin Choi, Drew R. Neavin, Jawairia Atif, Zoe A. Clarke, Ran Gao, Shruti Khare, Ziyi Li, Liesbet Martens, Abhishek Murti, , Gary D. Bader

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

bioRxiv · Jul 4, 2026 · PreprintGenomics

A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver Disease

Eleni Papachristoforou, Kexin Kong, Fabio Colella, Jacky Tam, Juliet Luft, Elena F. Sutherland, Stefan Alexander Veizades, Malgorzata Grzelka, Pak Kwan Qui, Ayma Asif, Ines Battle, Max A. Hammer, John R. Wilson‐Kanamori, George E. Finney, Ginerva Pistocchi, , Prakash Ramachandran

bioRxiv · Aug 27, 2025 · PreprintImmunology

The proportion of periportal mesenchyme to ductal epithelial cells acts as a proliferative rheostat in liver regeneration

Lucía Cordero-Espinoza, Timo N. Kohler, Anna M. Dowbaj, Bernhard Strauss, Olga Sarlidou, Clare Pacini, Ross Dobie, John R. Wilson‐Kanamori, Richard Butler, Palle Serup, Neil Cowan Henderson, Florian Hollfelder, Meritxell Huch

This study shows that the ratio of periportal mesenchyme to ductal epithelial cells regulates ductal cell proliferation during liver regeneration through Notch signaling.

bioRxiv · Sep 21, 2020 · PreprintDevelopmental Biology