Parkinson's disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
Adamantios Mamais, Richard D. Batchelor, Chairmandurai Aravindraja, Thomas B. Ladd, Austin J. Shute, Nitya Subrahmanian, Nunziata Maio, Chris D. Vulpe, Matthew J. LaVoie
This study shows that LRRK2 mutations disrupt iron homeostasis in neurons and astrocytes, leading to oxidative stress and ferroptosis.
Molecular Neurodegeneration · Jul 24, 2026Peer-reviewedNeuroscience