Thomas B. Ladd

Parkinson's disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes

This study shows that LRRK2 mutations disrupt iron homeostasis in neurons and astrocytes, leading to oxidative stress and ferroptosis.

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease

The paper identifies a conserved Aβ amyloid 'responsome' in human and mouse AD brains, showing how amyloid scaffolds proteins involved in disease pathology.

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

The paper compares microglial transcriptomic responses to Aβ peptide aggregates ex vivo and in vivo, finding distinct responses and highlighting the limitations of using ex vivo models to predict in vivo behavior.