Matthew J. LaVoie

This study shows that LRRK2 mutations disrupt iron homeostasis in neurons and astrocytes, leading to oxidative stress and ferroptosis.

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

This study shows that Rab8a and Rab10 deficiencies cause distinct lysosomal and Golgi defects in human neurons, with opposing effects on lysosomal pH and proteostasis of α-synuclein and tau.

This study shows that parkin reduces oxidative stress in mammalian brains by mediating H2O2 reduction and glutathione regeneration, but its absence leads to increased oxidative stress despite compensatory mechanisms.