Machine Learning-Driven Antigen Selection Reveals Conserved T-Cell Targets for Broad Coronavirus Vaccination
Lorenzo Federico, Alexandru Odainic, Katrine Persgård Lund, Ingrid Marie Egner, Katrin E. Wiese, Lisette A. H. M. Cornelissen, Hassen Kared, Richard Stratford, Sebastian Kapell, Brandon Malone, Marius Gheorghe, Pierre Machart, Raman Siarheyeu, Yuki Tanaka, Trevor Clancy, , Ludvig A. Munthe
This study identifies conserved T-cell targets across betacoronaviruses using machine learning and validates their immunogenicity through functional assays and mRNA vaccination in mice.
bioRxiv · Apr 3, 2026 · PreprintImmunology