Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer.
Yukimatsu Toh, Ling Wu, Jianghua Tu, Zhengdong Liang, Adela M. Aldana, Jake Jianjun Wen, Li Li, Sheng Pan, Julie Haewon Rowe, Martha E. Hensel, Carolyn L. Hodo, Rick A. Finch, Kendra S. Carmon, Qingyun J. Liu
This study develops and tests a camptothecin analog conjugate targeting LGR4/5/6 in CRC models, showing potent anti-tumor activity with minimal toxicity.
British Journal of Cancer · Aug 18, 2025Peer-reviewedPharmacology & Toxicology