Sheng Pan

This study shows that combining LGR5 and MET-targeting antibody-drug conjugates with different payloads improves efficacy and delays tumor relapse in colorectal cancer models.

The paper develops RSPO2-based peptibody-drug conjugates that target LGR4/5/6 receptors, showing potent anti-tumor activity in colorectal cancer and neuroblastoma models.

SLB-msSIM is a single-cell proteomic method that enhances sensitivity and robustness for analyzing cellular heterogeneity and EMT trajectories in pancreatic cancer cells.

This study develops and tests a camptothecin analog conjugate targeting LGR4/5/6 in CRC models, showing potent anti-tumor activity with minimal toxicity.

This study identifies SUMOylation of EPAC1 at K561 as a mechanism for cAMP-independent activation of EPAC1 through enhanced Rap1 interaction.

This study identifies over 10,000 N-glycoforms in human brain and finds reduced sialylation and N-glycan branching, along with increased mannosylation and truncation in Alzheimer's disease.