RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m6Am demethylation
Brittany A. Shimanski, Juan F. Marín, Marcin Warmiński, Kasun Dilshan Abeyrathne Eluwawalage, Lucas O. Calzini, Riley M McKeon, Joanna Kowalska, Jacek Jemielity, Jodi A. Hadden‐Perilla, Jeffrey S. Mugridge
This study identifies conserved aromatic residues in FTO that recognize the mRNA 5' cap and enhance m6Am demethylation, providing structural insights into FTO's selectivity for m6Am over m6A.
Journal of Biological Chemistry · Sep 17, 2026Peer-reviewedBiochemistry