Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry
Danielle Chin, Yongbo Luo, Yi Teng Lau, Nivedita Dutta, Zengyting He, Chaoran Yin, Riley M Williams, Siddharth Balachandran, Quentin Vicens, Peter Dröge, Dahai Luo
The paper presents cryo-EM structures of anti-Z-DNA antibodies bound to Z-DNA, revealing their recognition mechanism and lack of B-to-Z transition induction.
Nucleic Acids Research · Mar 28, 2026Peer-reviewedBiochemistry