The epidermal growth factor (EGF) receptor family network in cardiac hypertrophy and heart failure
Stephen J. Fuller, Susanna T.E. Cooper, Joshua J. Cull, Nikola ADAMCZYK, Charlotte Tapsell, Riley Pokora, John Spilletts, Philip Richard Dash, Peter H. Sugden, Angela Clerk
EGFR-family ligand mRNAs shift in failing human hearts; NRG1 and EGF drive distinct, differently ERBB2-dependent transcriptional programmes in rat cardiomyocytes; afatinib blunts mouse angiotensin II hypertrophy but worsens fibrosis.
bioRxiv · Oct 26, 2026 · PreprintBiochemistry✦ In-depth digest