Author

Joshua J. Cull

University of ReadingORCID 0000-0003-0776-3396Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Angela ClerkiD· 3 shared Susanna T.E. CooperiD· 3 shared Peter H. SugdeniD· 2 shared Philip Richard DashiD· 2 shared Alejandro Suárez‐BonnetiD· 1 shared Andrew C. CookiD· 1 shared Angus J.M. CameroniD· 1 shared Bernard M. SiowiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

Angela ClerkORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 26, 2026

✦ In-depth digest

The epidermal growth factor (EGF) receptor family network in cardiac hypertrophy and heart failure

Stephen J. Fuller, Susanna T.E. Cooper, Joshua J. Cull…·Angela Clerk

EGFR-family ligand mRNAs shift in failing human hearts; NRG1 and EGF drive distinct, differently ERBB2-dependent transcriptional programmes in rat cardiomyocytes; afatinib blunts mouse angiotensin II hypertrophy but worsens fibrosis.

1 citation

humanrat

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PhysiologybioRxivPreprintMay 16, 2025

Speckle-tracking echocardiography in preclinical mouse models: Implications for cancer therapy-related cardiac dysfunction from inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade

Eugene Duvenage, Susanna T.E. Cooper, Daniel Gattari…·Angela Clerk

This paper evaluates speckle-tracking echocardiography in mice to assess cardiac function and drug effects, finding it more sensitive than traditional methods in detecting regional changes.

1 citation

mouseimaging

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Developmental BiologyBiochemical JournalPeer-reviewedJun 22, 2022

PKN2 deficiency leads both to prenatal congenital cardiomyopathy and defective angiotensin II stress responses.

Jacqueline J. T. Marshall, Joshua J. Cull, Hajed Obaid Alharbi…·Peter J. Parker

This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.

9 citations

mouseexperimental assay

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