Angela Clerk

PKNs are required for cardiac hypertrophy induced by angiotensin II in mice

The paper investigates the role of PKN isoforms in cardiac hypertrophy induced by angiotensin II in mice, finding that Pkn1/3 are required for sustained hypertrophy while Pkn2 does not substitute for them.

The epidermal growth factor (EGF) receptor family network in cardiac hypertrophy and heart failure

EGFR-family ligand mRNAs shift in failing human hearts; NRG1 and EGF drive distinct, differently ERBB2-dependent transcriptional programmes in rat cardiomyocytes; afatinib blunts mouse angiotensin II hypertrophy but worsens fibrosis.

Speckle-tracking echocardiography in preclinical mouse models: Implications for cancer therapy-related cardiac dysfunction from inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade

This paper evaluates speckle-tracking echocardiography in mice to assess cardiac function and drug effects, finding it more sensitive than traditional methods in detecting regional changes.

PKN2 deficiency leads both to prenatal congenital cardiomyopathy and defective angiotensin II stress responses.

This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.